| abstract |
1. A benzamidine derivative having the general formula (1): wherein: R1 represents a hydrogen atom, a halogen atom, an alkyl group or a hydroxyl group; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom, an optionally substituted alkyl group, an aralkyl group, an optionally substituted alkylcarbonyl group, an optionally substituted alkylsulfonyl group, or the like, each of R4 and R5 represents a hydrogen atom, a halogen atom, a optionally substituted alkyl or carbamoyl group, or the like, R6 represents a hetero ring or the like, each of R7 and R8 represents a hydrogen atom, an alkyl group or the like, and n represents 0, 1 or 2; or a pharmacologically acceptable salt thereof; The benzamidine derivative and its salt have excellent inhibitory action of activated blood coagulation factor X, and is useful as a medicine for the therapy or prevention of a blood clotting disease. |