| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12R2001-01 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-205
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-181
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 |
| filingDate |
2005-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc9f4c4ad0fff7350feaa256eb5f24b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22ad2891891fa2e44a5f47cb8c9380af
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0cb133d2a32b188a844badb6179a17d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dda6edd6722402822594cdd11b5d4d77 |
| publicationDate |
2005-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CO-5540384-A2 |
| titleOfInvention |
METHODS FOR THE PREPARATION, ISOLATION AND PURIFICATION OF EPOTILONE B AND CRYSTALLINE STRUCTURES OF X-RAYS OF EPOTILE NA |
| abstract |
1. A procedure for the isolation of epothilone B from an epothilone-producing microorganism, characterized in that it comprises the steps that consist of: (a) fermenting a strain of the epothilone-producing microorganism in the presence of a resin that absorbs the epothilone B through a hydrophobic interaction; (b) collecting the resin in a water-based medium; (c) extracting the resin with a solvent selected to extract epothilone B and separating it from the water-based medium; and (d) crystallize the epothilone B from the extraction phase before a chromatography step. 2. The method according to claim 1, characterized in that the crystallized epothilone B of step (d) is substantially pure. The process according to claim 1, characterized in that the resin is extracted with a polar solvent. 4. The process according to claim 1, characterized in that the fermentation step further comprises feeding an additive capable of improving the amount of epothilone. B produced compared to the amount of epothilone A produced. |
| priorityDate |
2002-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |