| abstract |
Provide a compound of the formula (I) <EMI FILE = "00097143_1" ID = "1" MFI = JPEG> where R1 is selected from <EMI FILE = "00097143_2" ID = "2" MFI = JPEG> Where R3 is selected from H, alkyl, -COR4, - (CH2) theteroaryl, -CHR5R6, - (CH2) taryl, -SO2NR5R6 and -SO2R9; R4 is selected from H, -OR5, alkyl, alkylaryl, - (CH2) taryl, - ( CH2) theteroaryl, - (CH2) tOR5, - (CH2) tNR7R8, -CHR5R6 and -NR5R6 optionally forming a cyclic amino derivative; R5 and R6 are independently selected from H, alkyl, alkylaryl, haloaryl, - (CH2) taryl, ( CH2) theteroaryl and acyl; R7 and R8 are independently selected from H, alkyl, -COR9, SO2R9 and -CO2R9; and R9 is selected from H, alkyl, aryl and alkylaryl; R2 is selected from C (O) R9, C (O) R9, <EMI FILE = "00097143_3" ID = "3" IMF = JPEG> R2a is H or acyl, provided that when R3 is selected from alkyl, ( CH2) taryl, - (CH2) theteroaryl and -CHR5R6, R2a is H; X is N or CH; Y is selected from H, halogen, alkoxy and alkyl; and t is an integer from 0 to 4; or an optical isomer, enantiomer, diastereomer, racemate or racemic mixture thereof, or a pharmaceutically acceptable salt thereof. |