| abstract |
7-aza-indolin-2-ones substituted in 4 and its use as protein kinase inhibitors. The 7-aza-indolin-2-ones substituted in 4 specific herein have the formula 1 <EMI FILE = "00097184_1" ID = "1" IMF = JPEG> and its acceptable salts for pharmaceutical use, solvates, caltrates and prodrugs thereof, where R1, R2, R3, R4, X, Y, and Z are defined in the specification. The invention also relates to pharmaceutical compositions and dosage forms comprising the compounds of formula 1 and with methods for use in the treatment and / or prevention of diseases such as, for example, cancer. |