| abstract |
A modified peptide derived from H-Arg-Ser-Phe-Thr-Leu-Ala-Ser-Ser-Glu-Thr-Gly-Val-Gly-OH (formula I) having the general formula Q-A1-A2-A3 -A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-Z (formula II), where A1 to A13 correspond to the amino acids of formula I, Q corresponds to H and Z corresponds to OH , CHARACTERIZED because 1 to 6 modifications are selected from one or more of the groups a, b or c consisting of: a) substitution of 1-6, preferably 1-4 amino acids in A1 to A13 by unnatural amino acids or ß amino acids, b) substitution of one or more amide bonds by reduced amide bonds or isoesters of ethylene, c) substitutions in Q and / or Z: and optionally d) substitution by natural amino acids up to a total of 6 modifications. |