| abstract |
Substituted glutarimides, characterized by the general formula I <EMI FILE = "01003816_1" ID = "1" MFI = JPEG> in which X means a group of formula (CH2) n- (CR8R9) p-Z- (CR8R9) m; Z represents a sulfur or oxygen atom, the SO or SO2 group, the NR8 radical (if necessary in the form of the N oxide) or a CR8R9 group; m and p represent 0 or 1; n represents 0, 1, 2 or 3; where m, n and p cannot simultaneously be 0; R1 and R2 are the same or different and represent a carboxyl group, an ester group of formula COOR5 or an acyl group of formula COR5, groups in which R5 means in each case an alkyl group (straight or branched chain) with 1 to 6 C atoms (if any substituted with the COOR5 radical and / or a phenyl group), a C3 to C7 cycloalkyl group or a phenyl or benzyl radical; or an amide group of the formula CONR6R7, in which R6 and R7 are the same or different and represent hydrogen, an alkyl group (straight or branched chain) with 1 to 6 C atoms (if any substituted with the radical COOR5 and / or a phenyl group), the alkyl radical, the phenyl radical or, together with the N atom, the hydrazide group, the pyrrolidine ring, piperidine, hexamethyleneimine, morpholine, thiomorpholine, piperazine or N-methylpiperazine; or - 2 - hydrogen, bromine, chlorine, fluorine, a mono-, di- or trifluoromethyl, trityl, hydroxy, hydroxymethyl, trifluoromethoxy, nitro, amino group (if substituted with the radical CH (= O) or COR5 or a alkylsulfonyl) or dimethylamino group, an alkyl or alkoxy radical (straight or branched chain) with 1 to 6 C atoms, an amidine radical of the formula NH-CH (= NH) or NH-C (= NH) R5, a radical phenyl or a benzene ring bound by condensation (substituted if necessary with the above-mentioned atoms or groups); with the proviso that when Z = CR8R9, then R1 and R2 cannot simultaneously represent hydrogen, and when Z = S and m = 0, then R1 and R2 cannot represent the methoxy group; R3 represents hydrogen, the hydroxy radical or a group of formula CH2-NR6R7, in which R6 and R7 are defined above; R4 represents hydrogen, a C1 to C3 alkyl group, a fluorine atom, the difluoro- or trifluoromethyl group; R8 represents hydrogen, an alkyl group with 1 to 4 C atoms (straight or branched chain), the benzyl or phenethyl radical (if any substituted with the aforementioned atoms or groups); and R9 has the same meaning of R8 and represents the ester group of formula COOR5, the phenyl radical, the hydroxy group or an alkoxy radical (straight or branched chain) with 1 to 4 C atoms, a fluorine or chlorine atom, or the trifluoromethyl group; and its enantiomers, mixtures of enantiomers, racemates, diastereomers or mixtures of diastereomers in the form of their bases or salts of physiologically acceptable acids. |