| abstract |
Use of at least one substituted 4-amino-1-phenylbutane-2-ol compound of the general formula I <EMI FILE = "00097383_1" ID = "1" IMF = JPEG> in which A represents an aryl or heteroaryl radical , R1 and R2 may be the same or different from each other and represent a C1-6 -alkyl radical, preferably C1-3-alkyl, or R1 and R2 together form a (CH2) 2-6 cycle that may also be substituted with phenyl , R3 and R4 may be the same or different from each other and represent a C1-6-alkyl radical, preferably C1-3-alkyl, an aryl radical or an aryl radical linked through a C1-3-alkylene radical or the radicals R3 and R4 together form a group (CH2) 3-6 or CH2CH2OCH2CH2, R5, R6, R7 can be the same or different from each other and represent H, F, Cl, Br, 1, CF3, OR8, SO2CH3, SO2CF3, phenyl, CN, NO2 or a C1-6 alkyl radical, R8 represents H, a C1-6-alkyl radical, preferably C1-3-alkyl, or an aryl or heteroaryl radical linked through a C1-3-alkylene radical, in the form from their racemates, enantiomers, diastereomers or corresponding bases or salts with physiologically tolerable acids as the regulatory regulator ORL1 (opioid-like receptor) for the nociceptin / orphanin FQ system ligand of the ORL1 receptor. |