| abstract |
A composition for solid oral dose of extended release coated with a film containing a nasal decongestant, pseudoephedrine or its salt, for example, pseudoephedrine sulfate in an effective core such as to provide a geometric maximum plasma concentration of pseudoephedrine between about about 345 ng / ml and around 365 ng / ml in a time between about 7.60 hours and about 8.40 hours and having two or three film coatings on the core, the second contains an amount of antihistamine, not sedative, desloratadine, effective to provide a maximum geometric plasma concentration of desloratadine between about 2.15 ng / ml and about 2.45 ng / ml in a time between about 4.0 hours and about 4.5 hours, and the use of the composition to treat patients who show signs and symptoms associated with allergic and / or inflammatory conditions of the skin and airways. |