http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CO-5251383-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_34bd4e87ecbca17f16d460ca394e60f9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 2000-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95be756c16a65fd7da0cc795ea35f364 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f90ff35eb499c06de18720508d8c129f |
| publicationDate | 2003-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CO-5251383-A1 |
| titleOfInvention | BASES OF INDOLIC MANNICH, PROCEDURE FOR THE PREPARATION, MEDICATIONS CONTAINING THESE COMPOUNDS AND THEIR USE FOR THE PREPARATION OF MEDICINES |
| abstract | Indigenous Mannich bases substituted by the general formula I <EMI FILE = "00097385_1" ID = "1" MFI = JPEG> in which R1 represents H, a C1-10-alkyl radical or an aryl or heteroaryl radical linked through a C1-6-alkylene radical, R2 represents H, F, CI, Br, CF3, CN, NO2, NHR8, SR9, OR10, SO2NH2, SO2NHR21, CO (OR11), CH2CO (OR12), COR19, a C1-10 radical -alkyl, aryl or heteroaryl or an aryl or heteroaryl radical linked through a C1-6-alkylene radical, R3 represents CH (R13) N (R14) (R15), R4, R5, R6, R7 may be the same or different each other and represent H, F, CI, Br, CF3, CN, NO2, NHR8, SR9, OR10, SO2NH2, SO2NHR21, CO (OR11), CH2CO (OR12), COR19, C1-10-alkyl, aryl or heteroaryl or an aryl or heteroaryl radical linked through C1-6-alkylene, R8 represents H, COR16, C1-10-alkyl or aryl and preferably C1-6-alkyl, R9 represents H, C1-10-alkyl or aryl, preferably C1 -6-alkyl or phenyl, R10 represents H, COR17, C1-10-alkyl, aryl or an aryl or heteroaryl radical linked through C1-6-alkylene, R11 represents H, C1-10 alkyl or aryl, R12 represents H, C1-10 alkyl or aryl, R13 represents an unsubstituted or at least mono-substituted phenyl radical with C1-4-alkyl, C1-3-alkoxy, halogen, CF3, CN, O-phenyl or OH, R14 and R15 may be the same or different from each other and represent C-1-6-branched or unbranched alkyl, saturated or unsaturated, unsubstituted or al minus - 2 -monosubstituted, or phenyl, benzyl or phenethyl unsubstituted or at least monosubstituted, or R14 and R15 together form the radical (CH2) n where n is an integer from 3 to 6 or (CH2) 2O (CH2) 2 , R16 represents C1-10-alkyl, aryl or heteroaryl, R17 represents C1-10-alkyl, R18 represents C1-10-alkyl, aryl, heteroaryl or naphthyl R19 represents H, NHNH2, NHR20, C1-10-alkyl, aryl, heteroaryl or an aryl or heteroaryl radical linked through a C1-6-alkylene radical, R20 represents H, C1-10-alkyl, aryl or heteroaryl or an aryl or heteroaryl radical linked through C1-6-alk uylene R21 represents H, COR17, C1-10-alkyl, aryl or an aryl or heteroaryl radical linked through C1-6-alkylene and / or its racemates, enantiomers, diastereomers and / or the corresponding bases and / or the corresponding salts with physiologically tolerable acids, racemates being excluded from the compounds in which R3 represents CH (R13) N (R14) (R15) and some of the following alternatives are presented: R4 through R7 and R2 represent H, R13 represents phenyl, R14 and R15 together form (CH2) 5 and R1 represents H, CH3 or benzyl, oR4 to R7 and R2 represent H, R13 represents phenyl, R14, R15 represents two radicals CH3, and R1 represents H, CH3 or benzyl, or R4 to R7 and R1 represent H, R13 = 2-chloro-phenyl, R14 and R15 represent two radicals CH3 or R14 and R15 together represent (CH2) 2O (CH2) 2, R2 = COOR11 and R11 = C2H5 and the corresponding hydrochlorides, oR4 to R7 and R1 represent H, R13 = phenyl, R14 and R15 together form (CH2) 5, R2 represents COOR11 and R11 rep CH3 in the form of hydrochloride, oR4 to R7 and R2 represent H, R13 represents phenyl, R14 and R15 together form (CH2) 4, R1 represents H, CH3, CH2-CH = CH2 or 4-chlorobenzyl and for R1 = CH3 also the corresponding hydrochloride, o4 to R7 and R1 and R2 represent H, R3 represents phenyl, R14 represents phenyl and R15 represents 4-ethoxyphenyl, or R4 to R7 represents H, R13 represents 2,4,6-trimethoxyphenyl, R14 and R15 together they form (CH2) 2O (CH2) 2, R1 represents CH5 and R2 represents phenyl, oR4 through R7 and R1 represent H, R13 represents phenyl, 2-hydroxyphenyl or 2-hydroxy-5-methylphenyl, R14 and R15 together form (CH2 ) 5 and R2 represents CH3 and for R13 = phenyl also the corresponding bisulfate, oR4 through R7 and R1 represent H, R13 represents phenyl, R14 and R15 together form (CH2) 2O (CH2) 2, and R2 represents CH3 and the corresponding compound bisulfate, oR4 through R7 and R1 represent H, R13 represents phenyl, R14 and R15 together form (CH2) 5, R2 represents COOR11 and R11 represents sit CH3 as hydrochloride, oR1, R4, R6 and R7 represent H, R2 represents COOR11, R11 represents C2H5, R14 and R15 represent two radicals CH3, R13 represents 2-chlorophenyl and R5 represents 3 - [(2-chlorophenyl) -dimethylaminomethyl] -5-Methylene-1H-indole-2-carboxylate ethyl or 3 - [(2-chlorophenyl) -dimethylaminomethyl] -5-hydroxate-1H-indole-2-carboxylate ethyl. |
| priorityDate | 1999-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.