http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CO-5200773-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a4d7b8b2733b3bf3f7283c1634f88292 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-565 |
| filingDate | 2000-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_428d3cbc2ae1cec361170ad659214062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e393345594239ab8d87bf8e70a17407f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5634e2d14cb941e5be6949efe064ee5f |
| publicationDate | 2002-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CO-5200773-A1 |
| titleOfInvention | MESOPROGESTINES (RECEIVER MODULATORS FOR PROGESTERON) AS A COMPONENT OF COMPOSITIONS USED FOR HORMONAL REPLACEMENT THERAPY (HRT) |
| abstract | The present invention refers to the use of mesoprogestins as pharmaceutical components for the manufacture of a medicament for hormone replacement therapy (HRT) and as a component for combined use with an estrogen for the manufacture of a medicament for HRT as well as in respective HRT methods and methods to treat hormonal insufficiency and hormonal irregularity symptoms. Mesoprogestins are defined as compounds that have both agonistic and antagonistic activities in the progesterone receptor (RP) in vivo. They stabilize the function of RP at an intermediate level between agonistic and antagonistic. Progestins and antiprogestins do not allow corresponding functional states to be achieved. J867, J912, J956 and J1042 are the preferred mesoprogestins according to the invention. Figures 1A and 1B progesterone-like effects (above, Figure 1A) and progesterone antagonists (below, Figure 1B ) of RP modulators in the uterus of immature rabbits prepared with estrogen (McPhail test). Figure 1A: McPhail result <EMI FILE = "00065516_1" ID = "1" MFI = JPEG> vehicle - progesterone - RU486 - J867 - J956 - J1042 Figure 1B: McPhail result <EMI FILE = "00065516_2" ID = "2" MFI = JPEG> mg / animal / day (dose of test substances + 1.0 mg of progesterone). |
| priorityDate | 1999-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.