abstract |
A compound of formula (I): <EMI FILE = "00049344_1" ID = "1" MFI = JPEG> in which: Q is a monocyclic or bicyclic aryl or heteroaryl ring; R1 is hydrogen; R2 is hydrogen or up to three substituents selected from halogen, NO2, CN, N3, CF3-O-, CF3-S, CF3-SO2-, CF3CO-, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl C1-6 perfluoroalkyl, C3- cycloalkyl 6, C 3-6 cycloalkyl-C 1-4 alkyl, C 1-6 alkyl-O-C 1-6 alkyl-, C 3-6 cycloalkyl, C 3-6 cycloalkyl, C 3-6 alkyl-C 1-4 alkyl -O-, C3-6 cycloalkyl-C1-4-CO- alkyl, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4 alkyl, C1-6-S- alkyl, C1-6-SO2- alkyl, (alkyl C1-4) 2-NSO2-, (C1-4 alkyl) -NHSO2-, (C1-4 alkyl) 2-NCO-, (C1-4 alkyl) -NHCO- or CONH2, or -NR3R4 where R3 is hydrogen or C1-4 alkyl, and R4 is hydrogen, C1-4 alkyl; formyl, -CO2-C1-4 alkyl or -CO-C1-4 alkyl, or two R2 groups together form a carbocyclic ring that is saturated or unsaturated, unsubstituted or substituted with -OH u = O; X is halogen; C1-6 alkoxy, C1-6 alkyl or perfluoroalkyl C1-6, eY is hydrogen, halogen, C1-6 alkoxy, C1-6 alkyl or perfluoroalkyl C1-6; but excluding compounds N- (5-iodo-1,2 , 3,4-tetrahydroisoquinolin-7-yl) -4-azidobenzamide and N- (5-iodo-1, 2,3,4-tetrahydroisoquinolin-7-yl) -5-benzoyl-2-methoxybenzamide; or a salt or a pharmaceutically acceptable solvate thereof. |