| abstract |
A method for treating chronic pain, said method characterized in that it comprises administering to a subject in need of treatment, a composition comprising an MEK inhibitor selected from a compound of the following formula (I): <EMI FILE = "00053306_1" ID = "1" MFI = JPEG> where W is OR1, NR2OR1, NRARB, NR2NRARB, O (CH2) 2-4 NRARB, or NR2 (CH2) 2-4 NRARB; R1 is H, C1-8 alkyl, alkenyl of C3-8, C3-8 alkynyl, C3-8 cycloalkyl, phenyl, C4-4 (phenyl) alkyl, C3-4 (phenyl) alkenyl, (C3-4 phenyl) alkynyl, (C3- cycloalkyl) 8) C1-4 alkyl, ((C3-8 cycloalkyl) C3-4 alkenyl, (C3-8 cycloalkyl) C3-4 alkynyl, C3-8 heterocyclic radical, (C3-8 heterocyclic radical) C1-4 alkyl, (C3-8 heterocyclic radical) C3-4 alkenyl, (C3-8 heterocyclic radical) C3-4 alkynyl or (CH2) 2-4 NRCRD; R2 is H, C1- alkyl 4, phenyl, C3-6 cycloalkyl, C3-6 heterocyclic radical, or (C3-6 cycloalkyl) methyl; RA is H, alkyl C1-6, C3-8 alkenyl, C3-8 alkynyl, C3-8 cycloalkyl, phenyl, (C3-8 cycloalkyl) C1-4 alkyl, (C3-8 cycloalkyl) C3- alkenyl 4, (C3-8 cycloalkyl) C3-4 alkynyl, C3-8 heterocyclic radical, (C3-8 heterocyclic radical) C1-4 alkyl, (aminosulfonill) phenyl, [(aminosulfonyl) phenyl] C1 alkyl -4, (aminosulfonyl) C1-6 alkyl, (aminosulfonyl) C3-6 cycloalkyl, [(aminosulfonyl) C3-6 cycloalkyl] C1-4 alkyl, or (CH2) 2-4 NRCRD; RB is H, C1-8 alkyl, C3-8 alkenyl, C3-8 alkynyl, C3-8 cycloalkyl, or phenyl; Q is one of the following formulas (i) - (iii): <EMI FILE = "00053306_2" ID = "2" IMF = JPEG> R3 is H or F; R4 is halo, NO2, SO2NRO (CH2) 2-4NRERF, SO2NRERF or (CO) T; T is C1-8 alkyl, C3-8 cycloalkyl, ( NRERF) C1-4 alkyl, ORF, -NRO (CH2) 2-4NRERF, or NRERF; ... |