http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CO-5170417-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c76ecadad74a1a35270b3e3a34d60f37 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D275-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-44 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D275-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D275-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-10 |
| filingDate | 2000-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b41f851d28cc0849bb9fa03f0b7ff74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9079b640c0f6b110b418a253e8445618 |
| publicationDate | 2002-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CO-5170417-A1 |
| titleOfInvention | USEFUL HETEROCICLIC DERIVATIVES AS ANTI-TARGET AGENTS |
| abstract | A compound of formula I: <EMI FILE = "00028307_1" ID = "1" MFI = JPEG> or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein: Z is S, O, or NR6; X is N or CR4; X1 is O, S, SO, SO2, NR6 or CR5R6; R is -CONR5R6, -C02R5, -NR5R6, -NR5SO2R6, -SO2NR5R6, -NR6C (O) R5 or a C6-C10 aryl or a 4-10 membered heterocyclic group containing 1-4 heteroatoms of group N, O, S or S02; R1 is H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, - (CH2) t (C6-C10 aryl) or - (CH2) t (4-10 membered heterocyclic), in those that t is an integer from 0 to 5; said alkyl group optionally includes 1 or 2 hetero moieties selected from O, S and -N (R5) - with the proviso that two O atoms, two S atoms, or an O and S atom are not directly linked to each other ; said aryl and heterocyclic R1 groups being optionally fused to a C6-C10 aryl group, a C5-C8 saturated cyclic group, or a 4-10 membered heterocyclic group; 1 or 2 carbon atoms being in the aforementioned heterocyclic moieties optionally substituted by an oxo moiety (= O); optionally including the residues - (CH2) t- of the preceding R1 groups a double or triple carbon-carbon bond being t an integer from 2 to 5, and the preceding R1 groups different from H are optionally substituted by 1 to 5 R8 groups ; R2 is H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, -C (O) (C1-C10 alkyl), - (CH2) t (C6-C10 aryl) or - (CH2) t ( 4-10 membered heterocyclic), -C (O) (CH2) t (C6-C10 aryl) or -C (O) (CH2) t (4-10 membered heterocyclic), in which t is an integer from 0 to 5; said alkyl group optionally includes 1 or 2 hetero moieties selected from O, S and -N (R6) - with the proviso that two O atoms, two S atoms, or one O and S atom are not directly linked to each other ; said aryl and heterocyclic R1 groups being optionally fused to a C6-C10 aryl group, a C5-C8 saturated cyclic group, or a 4-10 membered heterocyclic group; 1 or 2 carbon atoms in the aforementioned heterocyclic moieties are optionally substituted by an oxo moiety (= O); optionally including the moieties - (CH2) t- of the preceding R1 groups a double or triple carbon-carbon-2 bond - t being an integer from 2 to 5, and the preceding R1 groups, except H, are optionally substituted by 1 to 5 groups R8; R3 is -CR5R6R7, -S02R5, -CONR5R6; R4 is H or C1-C6 alkyl and can be taken together with X1 or R1 to form a 5 to 6 membered saturated ring or a 5 to heteroaryl ring 6 members, including said heteroaryl and optionally saturated rings of 1 to 3 heteroatoms in addition to X1, selected from O, S and -N (R6) -, wherein said -N (R6) - is optionally = N- or -N =, optionally said saturated ring may be partially unsaturated by inclusion of 1 or 2 carbon-carbon double bonds, and said saturated and heteroaryl rings, including the R6 group of said -N (R6) - are optionally substituted by 1 to 5 R8 groups; R5 is independently H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, -C (O) (C1-C10 alkyl), - (CH2) t (a C6-C10 ryl), - (CH2) t (4-10 membered heterocyclic), -C (O) (CH2) t (C6-C10 aryl) or -C (O) (CH2) t (4- heterocyclic 10 members), in which t is an integer from 0 to 5; said alkyl group optionally includes 1 or 2 hetero moieties selected from O, S and -N (R6) - with the proviso that two O atoms, two S atoms, or one O and S atom are not directly linked to each other; said aryl and heterocyclic R1 groups being optionally fused to a C6-C10 aryl group, a C5-C8 saturated cyclic group, or a 5-10 membered heterocyclic group; 1 or 2 carbon atoms being in the above-mentioned heterocyclic moieties optionally substituted by an oxo moiety (= 0); optionally including the moieties - (CH2) t- of the preceding R1 groups a double or triple carbon-carbon bond being t an integer from 2 to 5, and the preceding R1 groups except H, are optionally substituted by 1 to 5 groups R8; each R6 is independently selected from the list of substituents provided in the definition of R5, -SO2 (CH2) t (C6-C10 aryl), -SO2 (CH2) t (4-10 membered heterocyclic), and -OR5 , t is an integer from 0 to 5, the moieties - (CH2) t- of the R2 groups optionally include a double or triple carbon-carbon bond being t an integer from 2 to 5, and the preceding R6 groups are optionally substituted by 1 to 5 R8 groups; each R7 is independently H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, -C (O) (C1-C10 alkyl), - (CH2) t (C6 aryl- C10), - (CH2) t (4-10 membered heterocyclic), -C (O) (CH2) t (C6-C10 aryl) or -C (O) (CH2) t (4-10 membered heterocyclic) , in which t is an integer from 0 to 5; said alkyl group optionally includes 1 or 2 hetero moieties selected from O, S and -N (R6) - with the proviso that two O atoms, two S atoms, or one O and S atom are not directly linked to each other ; said aryl and heterocyclic R1 groups being optionally fused to a C6-C10 aryl group, a C5-C8 saturated cyclic group, or a 4-10 membered heterocyclic group; 1 or 2 carbon atoms being in the aforementioned heterocyclic moieties optionally substituted by an oxo moiety (= O); optionally including residues - (CH2) t- of the preceding R1 groups a double or triple carbon-carbon bond being t an integer from 2 to 5, and the preceding R7 groups, except H, being substituted by 1 to 5 groups R8; or R5 and R6 may be taken together with the nitrogen to which each is attached, to form a saturated 4 to 10 membered monocyclic or polycyclic ring or a 5 to 10 membered heteroaryl ring, including said saturated and optionally heteroaryl rings or 2 heteroatoms selected from O, S and -N (R6) - in addition to the nitrogen to which R5 and R6 are attached, said -N (R6) - is optionally = N- or - N = R5 and R6 being taken together as said group heteroaryl, said saturated ring may be partially unsaturated by inclusion of 1 or 2 carbon-carbon double bonds, and said heteroaryl and saturated rings, which including the R6 group of said -N (R6) -, are optionally substituted by 1 to 5 groups R8; each R8 is independently selected H te, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, halogen, cyano, nitro, trifluoromethyl, trifluoromethoxy, azido, -OR5, -C (O) R5, -C (O) OR5, -NR6C (O) OR5, -OC (O) R5, -NR6S02R5, -SO2NR5R6, -NR6C (O) R5, -C (O) NR5R6, -NR5R6, -S (O) jR7 in which j is an integer number of 0 to 2, -S03H, -NR5 (CR6R7) tOR6, - (CH2) t (C6-C10 aryl), -SO2 (CH2) t (C6-C10 aryl), - S (CH2) t (C6-C10 aryl ), -O (CH2) t (C6-C10 aryl), - (CH2) t (4-10-membered heterocyclic), and - (CR6R7) mOR6, where m is an integer from 1 to 5 and t is an integer from 0 to 5; said alkyl group optionally contains 1 or 2 hetero moieties selected from O, S and -N (R6) - with the proviso that two O atoms, two S atoms, or one O atom and one S atom are not directly united to each other; said aryl and heterocyclic R4 groups are optionally fused to a C6-C10 aryl group, a C5-C8 saturated cyclic group, or a 4- to 10-membered heterocyclic group; 1 or 2 carbon atoms in the above-mentioned heterocyclic moieties are optionally substituted by an oxo moiety (= O); and the alkyl, aryl and heterocyclic moieties of the above-mentioned R8 groups are optionally substituted by 1 to 5 substituents independently selected from -3-halogen, cyano, nitro, trifluoromethyl, trifluoromethoxy, azido, -NR10SO2R9, -SO2NR9R10, -C (O ) R9, -C (O) OR9, -OC (O) R9, -NR10C (O) R9, -C (O) NR9R10, -NR9R10), - (CR10R7) mOR10 where m is an integer of 1 at 5, and R9 and R10 are each defined as H, C1-C6 alkyl, -CH2) t (C6-C10 aryl) or - (CH2) t (4-10 membered heterocyclic) and t is an integer of 0 to 5. on the condition that when X1 is 0 then simultaneously Z is not S; X is not N; R is not CONH2; R2 is not H; and R3 is not CONR5R6 and when X1 is S then simultaneously Z is not S; X is not N; R is not CONH2; R2 is not H; and R3 is not CONR5R6. |
| priorityDate | 1999-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 39.