| abstract |
A compound of the formula: <EMI FILE = "99078843_1" ID = "1" MFI = JPEG> or a pharmaceutically acceptable salt or solvate thereof where: where one of a, b, c and d represent N or N + O, and the groups a, b, c and remnants represent CR1 or CR2; or each of a, b, c and d are independently selected from CR1 or CR2; X represents N or CH where the optional link (represented by the dotted line) is absent, and represents C when the optional link is present; the dotted line between carbon atoms 5 and 6 represents an optional bond, so that when a double bond A and B is present they independently represent -R15, halo, -OR16, -OCO2R16, OC (O) R15, and when not no bond is present between carbon atoms 5 and 6, A and B each independently represent H2, -O (OR16) 2, -H and halo, dihaIo, alkyl and H, (alkyl) 2, -H and -OC (O) R15, H and -OR15, = O, Aryan and H, = NOR15 or -O- (CH2) pO- (where p is 2, 3, or 4; each R1 and each R2 is independently selected from H, halo, -CF3, -OR15, -COR15; -SR15, -S (O) tR16 (where t is 0, 1 or 2, -NR (R15) 2, -NO2, -OC (O) R15, -CO2R15, -OCO2R16, -CN, -NR15COOR16, -SSR16C (O) OR16, -SR16N (R17) 2 (with the proviso that R16 in -SR16N (R17) 2 is not -CH2-), where each R17 is independently selected from H or -C (O) OR16, benzotriazol-1-yloxy, tetrazol-5-ylthio, or substituted tetrazol-5-ylthium, alkynyl, alkenyl or alkyl, said alkyl or alkenyl group being optionally substituted with halo, -OR15 or -CO2R15; R3 and R4 are the same or different and each independently represents H, any of the substituents of R1 and R2, or R3 and R4 taken together represent a fused ring C5-C7 saturated or unsaturated with the becene ring (Ring III) .R5, R6 and R7 each independently represents H, -CF3, -COR15, alkyl or aryl, said alkyl or aryl being optionally substituted with -OR15, -SR15, -S (O) tR16, - NR15COOR16, -N (R15) 2, -NO2, -COR15, -OCOR15, -OCO2R16, -CO2R15, OPO3R15, or R5 is combined with R6 to present = O or = S; ... |