| abstract |
A bicyclic heteroaromatic derivative compound according to general formula I, or a pharmaceutically acceptable salt thereof, <EMI FILE = "00025852_1" ID = "1" IMF = JPEG> CHARACTERIZED because R1 is NR5R6, OR5, SR5 or R7; R5 and R6 are independently selected from H, alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), cycloalkyl (3-8C), heterocycloalkyl (2-7C), alkyl (1-8C) carbonyl, arylcarbonyl (6-14C), aryl (6-14C) or heteroaryl (4-13C), or R5 and R6 together are attached in a heterocycloalkyl ring (2-7C); R7 is cycloalkyl (3-8C), heterocycloalkyl ( 2-7C) aryl (6-14C) or heteroaryl (4-13C), R2 is alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), or aryl (6-14C) or heteroaryl (4-13C), both optionally substituted with one or more substituents selected from alkyl (1-8C), alkylthio (1-8C), (d) alkylamino (1-8C), alkoxy (1-8C), alkenyl (2 -8C), or alkynyl (2-8C); R3 is alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), cycloalkyl (3-8C), heterocycloalkyl (2-7C), or aryl (6-14C) or heteroaryl or (4-13C), both optionally with one or more substituents selected from (C1-8C) alkyl, (di) alkylamino (1-8C) or alkoxy (1-8C); X is S, O, or N (R4 ); R4 is H, alkyl (1-8C), alkylcarbonyl (1-8C), arylcarbonyl (6-14C) or aryl (6-14C) alkyl (1-8C); Y is CH or N; Z is NH2 or OH; A is S, N (H), N (R9), 0 or a link, R9 can be selected from the same groups as described for R2; B is N (H), 0, or a link, for use in therapy. |