http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CO-5160342-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f6fbe16bb6eb71437624a2b0a68a2ae5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-295 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-295 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-191 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 |
| filingDate | 1999-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f02079e28c7dd23762cbfe7bfdb0f95 |
| publicationDate | 2002-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CO-5160342-A1 |
| titleOfInvention | METHOD FOR PREPARING AN EFFECTIVE GRANULATE THAT INCLUDES IRON GLUCONATE, GRANULATE AS GOT AND COMPRESSED CONTAINING IT |
| abstract | Method for preparing an effervescent granulate comprising, as a pharmacologically active ingredient, ferrous gluconate and, as an effervescent system, citric acid and sodium bicarbonate, by wet granulation in a fluid bed granulator, characterized in that it comprises the following phases of: I. introducing a mixture comprising ferrous gluconate, citric acid and sodium bicarbonate, in said granulator while it is fed with a flow of air heated to 70 ° C and having an ANDlt humidity; 1.0 g / kg; II. moisten said mixture with water mist when it has reached a temperature of 35 ° C; III. evaporate the mist water, keeping the temperature of said mixture constant at 35 ° C; IV. repeat phases II and III until a granulate having the desired characteristics has been formed, and V. drying said granulate with air heated to 80 ° C until its moisture content is ANDlt; 0.5% by weight. Method according to claim 1, characterized in that in phase I the entity of the air flow is between 3200 and 3800m3 / hour for each batch of approximately 265 kg of mecla to be granulated. Method according to claim 1 or 2 characterized in that in phase II the flow of water mist is preferably between 500 and 2000 ml / min. Method according to any of claims 1 to 3, characterized in that in phase II the pressure of the flow of water mist is 303975 Pascals Effervescent granulate obtained according to any of claims 1 to 4, and comprising from 7 to 35% by weight of ferrous gluconate, from 25 to 45% by weight of citric acid and from 15 to 25% by weight of bicarbonate of sodium. Effervescent granulate according to claim 5 characterized in that it also comprises from 5 to 18% by weight of sorbitol, approximately 2% by weight of L-Ieucine, from 5 to 11% by weight of aromas. Granule according to claim No. 5, characterized in that the ferrous gluconate is in the form of dihydrate. Compressed obtained by compression of effervescent granulate obtained, in turn, according to any of claims 1 to 4, said tablet comprising 7 to 35% by weight of ferrous gluconate, from 25 to 45% by weight of citric acid, from 15 to 25% by weight of sodium bicarbonate, from 5 to 18% by weight of sorbitol, about 2% by weight of L-leucine and from 5 to 11% by weight weight of aromas. |
| priorityDate | 1998-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.