| abstract |
Triazole compounds of the general formula 1. <EMI FILE = "00001268_1" ID = "1" IMF = JPEG> wherein R1 represents H, C1-C6 alkyl optionally substituted by OH, OC1-C6 alkyl, halogen or phenyl; C3-C6 cycloalkyl or phenyl; R2 represents H, C1-C6 alkyl optionally substituted by OH, OC1-C6 alkyl, halogen or phenyl; C1-C6 alkoxy, C1-C6 alkylthio, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, halogen, CN, COOR3, CONR3R4, NR3R4, SO2R3, SO2NR3R4, or an aromatic moiety, selected from phenyl, naphyl and a 5 or 6 membered heterocyclic moiety with 1, 2, 3 or 4 heteroatoms, independently selected from each other from O, N and S; the aromatic moiety may have one or two substituents, independently selected from each other from C1-C6 alkyl optionally substituted by OH, OC1-C6 alkyl, halogen or phenyl; C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, halogen, CN, COR3, NR3R4, NO2, SO2R3, S02NR3R4 and phenyl optionally substituted by one or two moieties independently selected from each other C1- alkyl C6, C1-C6 alkoxy, NR3R4, CN, CF3, CHF2 or halogen; R3 and R4 independently represent one another H, C1-C6 alkyl optionally substituted by 0H, OC1-C6 alkyl, halogen or phenyl; or phenyl; A represents C4-C10 alkylene or C3-C10 alkylene, comprising at least one group Z, selected from O, S, CONR3, COO, CO, C3-C6 cycloalkyl and a double or triple bond; B means a remainder of the following formula: <EMI FILE = "00001268_2" ID = "2" MFI = JPEG> Where X represents CH2 or CH2CH2; R6, R7 and R8 independently selected from each other among H; C1-C6 alkyl optionally substituted by OH, - 2-OC1-C6 alkyl optionally substituted by amino, mono- or di-C1-C4 alkylamino; C1-C6 alkylthio, halogen or phenyl; OH, C1-C6 alkoxy, OCF3, OSO2CF3, SH, C1-C6 alkylthio, C2-C6 alkenyl, C2-C6 alkynyl, halogen, CN, NO2, CO2R3, SO2R3, SO2NR3R4, where R3 and R4 have the above-mentioned meaning and together with the N atom, to which they are linked, they can also form a saturated or unsaturated heterocycle with 5 to 7 ring atoms and 1 or 2 N heteroatoms; CONR3R4, NHSO2R3, NR3R4, a carbocyclic aromatic or non-aromatic ring of 5 or 6 members and a 5- or 6-membered heterocyclic aromatic or non-aromatic ring with 1 or 2 heteroatoms, independently selected from each other from O, N and S; the carbocyclic or heterocyclic ring may have one or two substituents independently selected from each other from C1-C6 alkyl, phenyl, phenoxy, halogen, C1-C6 alkoxy, OH, NO2, CF3 and CHF2, and two of the substituents R6, R7 being possible and R8 together with the carbon atom of the phenyl ring, to which they are attached, form a phenyl, pentyl or cyclohexyl ring fused to the phenyl ring, wherein one or two of the CH or CH2 groups can be replaced by a nitrogen atom , or an NH or N-C1-C6 alkyl group, as well as its salts with physiologically compatible acids. |