http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CO-5140116-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-14 |
| filingDate | 1999-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26ed63498df2f132abcd2844e74e774d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df89ad17efbbbb2caf93ae1dd5fca42a |
| publicationDate | 2002-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CO-5140116-A1 |
| titleOfInvention | ESPIRO COMPOUNDS DERIVED FROM IMIDAZO-BENZAZEPINA WITH ANTIHISTAMINAL ACTIVITY AND ITS OBTAINING PROCESSES FROM ITS SYNTHESIS INTERMEDIARIES |
| abstract | A CHARACTERIZED compound because it has the formula <EMI FILE = "99079021_1" ID = "1" IMF = JPEG> a prodrug, an N-oxide, an addition salt, a quaternary amine or a stereochemically isomeric form thereof, where R1 is hydrogen , C1-6alkyl, halogen, formyl, carboxyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyl, N (R3R4) C (= O) -, N (R3R4) C (= O) N (R5) -, carboxyl substituted ethenyl or C1-6alkyloxycarbonyl, or C1-6alkyl substituted with hydroxy, carboxyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, N (R3R4) C (= O) -, C1-6alkyl (= O) N (R5) -, C1-6alkIS ( = O) 2N (R5) -, or N (R3R4) C (= O) N (R5) -; where each R3 and each R4 are independently hydrogen or C1-4alkyl; R5 is hydrogen or hydroxy; R2 is hydrogen, C1 -6alkyl, hydroxyC1-6alkyl, C1-6alkyloxyC1-6alkyl, N (R3R4) C (= O) -, aryl or halogen; n is 1 or 2; -AB- represents a bivalent radical of formula -Y-CH = CH- (a-1); - CH = CH-Y- (a-2); ó-CH = CH-CH = CH- (a-3); where each hydrogen atom in the radicals (a-1) to (a-3) can be independently replaced by R6, where R6 is selected from C1-6alkyl , halogen, hydroxy, C1-6alkyloxy, ethenyl substituted with carboxyl or C1-6alkyloxycarbonyl, hydroxyC1-6alkyl, formyl, carboxyl and hydroxycarbonyC1-6-alkyl; each Y is independently a bivalent radical of the formula -O-, -S- or - NR7-; where R7 is hydrogen, C1-6alkyl or C1-6alkylcarbonyl; Z is a bivalent radical of formula- (CH2) p- (b-1), - CH = CH- (b-2), - CH2-CHOH - (b-3), - CH2-0- (b-4), - CH2-C (= 0) - (b-5), or-CH2-C (= NOH) - (b-6), always that the bivalent radicals (b-3), (b-4), (b-5) and (b-6) are connected to the imidazole ring nitrogen by its portion -CH2-; where p is 1,2,3 , or 4; - 2 -L is hydrogen; C1-6alkyl; C2-6alkenyl; C1-6-alkylcarbonyl; C1-6 alkyloxycarbonyl; C1-6alkyl substituted with one or more substituents, each independently selected from hydroxy, carboxyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, aryl, aryloxy, cyano or R8HN- where R8 is hydrogen, C1-6alkyl, C1-6 alkyloxycarbonyl, C1 -6 alkylcarbonyl; óL represents a radical of formula-Alk -Y-Het1 (c-1), Alk-Het3 (c-3); where Alk represents C1-4alkanediyl; Y represents O, S or NH; Het1 represents pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl, each optionally substituted with C1-4alkyl, C1-4alkyloxy, amino, hydroxy or halogen; yHet3 represents furanyl, tetrahydrofuranyl, thienyl, oxazolyl, thiazolyl or imidazolyl, each optionally substituted with one or two C1-4alkyl substituents; pyrrolyl or pyrazolyl, optionally substituted with formyl, hydroxyC1-4alkyl, hydroxycarbonyl, C1-4alkyloxycarbonyl or with one or two C1-4alkyl substituents; thiadiazolyl or oxadiazolyl optionally substituted with amino or C1-4 alkyl; Het3 may also represent 4,5-dihydro-5-oxo-1H-tetrazolyl substituted with C1-4alkyl, 2-oxo-3-oxazolidinyl, 2,3-dihydro- 2-oxo-1H-benzimidazol-1-yl or a radical of formula <EMI FILE = "99079021_2" ID = "2" IMF = JPEG> where A-Z represents S-CH = CH, S-CH2-CH2, S- CH2-CH2-CH2, CH = CH-CH = CH, or CH2-CH2-CH2-CH2; aryl is phenyl or phenyl substituted with 1, 2 or 3 substituents, each independently selected from halogen, hydroxy, C1-4alkyl, polyhaloC1-4alkyl, cyano, aminocarbonyl, C1-4alkyloxy or polyhaloC1-4alkyloxy; provided that 5,6-dihydrospiro [imidazo [1,2-b] [3] benzazepine-11 [11H], 4'-piperidine] and its Pharmaceutically acceptable addition salts are not included. |
| priorityDate | 1998-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.