| abstract |
Procedure for the preparation of a medicament for the treatment of disorders by excess of substance P characterized by an aryl (or heteroaryl) azolylcarbinol derivative of the general formula (I) <EMI FILE = "99049291_1" ID = "1" MFI = JPEG > where Ar is a phenyl radical or a thienyl radical, unsubstituted or optionally substituted by 1, 2 or 3 identical or different substituents, selected from the group consisting of fluorine, chlorine, bromine, trifluoromethyl and methoxy; R1 is a hydrogen atom, a cyclohexyl group, an N-methylpiperidyl group, a phenyl group, a vinyl group or a C1-C4 alkyl group; R2 is a hydrogen atom, a dialkyl (C1-C4) aminoalkyl (C2) radical -C3), (C1-C2) alkyl azaheterocyclylalkyl (C2-C3), or azaheterocyclylalkyl (C2-C3) alkyl; yHet is a five-membered nitrogen aromatic heterocycle containing one to three nitrogen atoms, unsubstituted or optionally substituted by 1 or 2 identical or different substituents selected from the group consisting of fluorine, chlorine, bromine, a C1-C12 alkyl group, a benzyl radical, a cyanoalkyl radical (C2-C3), a carboxyalkyl radical (C2-C3), a methoxycarbonylalkyl radical (C2-C3), a hydroxyalkyl radical (C2-C3), an aminoalkyl radical (C2-C3), a dialkyl (C1-C4) amino (C2-C3) alkyl radical and an azaheterocyclylalkyl (C2-C3) radical; or of one of its physiologically acceptable salts, Procedure for opting a medicament for the treatment of disorders that are mediated by an excess of substance P, especially certain disorders of the central nervous system, in mammals including man. |