http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CO-5080735-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-425 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-20 |
| filingDate | 1998-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49103a35386959d4f56a852abc47cd90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7fdbe758c0c652f16e6c70495ee6033 |
| publicationDate | 2001-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CO-5080735-A1 |
| titleOfInvention | PROSTAGLANDIN AGONISTS |
| abstract | A compound of formula 1: <EMI FILE = "98035644_1" ID = "1" IMF = JPEG> a prodrug thereof or the pharmaceutically acceptable salts of said compounds and prodrugs in which A is hydrogen or hydroxy; B is propylene, propenylene or propynylene; Q is propylene, -CH2 OCH2 -, thiazolyl, pyridyl, phenyl or thienyl; Z is carboxyl, (C 1 -C 6) alkoxycarbonyl, tetrazolyl, 1,2,4-oxadiazolyl or 5-oxo-1,2,4-oxadiazolyl; K is ethylene or ethenylene; L is a bond or ethenylene; L is a bond or -CO-; M is -Ar, -Ar1-V-Ar2, -Ar1 -S-Ar2 or -Ar1-0-Ar2, with Ar and Ar1 or (1) each independently being a ring of five to eight elements completely unsaturated and that optionally it has one to four heteroatoms independently selected from oxygen, sulfur and nitrogen, or a bicyclic ring consisting of two rings of five swims independently between oxygen, sulfur and nitrogen, or a bicyclic ring consisting of two rings of five and / or six elements condensed, partially saturated, fully saturated or fully unsaturated, considered independently, which optionally have one to four heteroatoms independently selected from nitrogen, sulfur and oxygen, or a tricyclic ring consisting of three rings of five and / or six condensed elements, partially saturated , fully saturated or totally unsaturated, considered independently, which optionally has one to four heteroatoms selected independently between nitrogen, sulfur and oxygen, any of said partially saturated or fully saturated rings optionally having one or more oxo groups substituted on carbon, or (2) each independently a ring of five to eight fully saturated elements; Ar2 is a ring of five to eight elements partially saturated, fully saturated or totally unsaturated and optionally having one to four heteroatoms independently selected from oxygen, sulfur and nitrogen, or a bicyclic ring consisting of two rings of five and / or six elements condensed, partially saturated, fully saturated or fully unsaturated, considered independently, which optionally have one to four heteroatoms independently selected from nitrogen, sulfur and oxygen, or a tricyclic ring consisting of three rings of five and / or six condensed elements, partially saturated , fully saturated or fully unsaturated, considered independently, which optionally has one to four heteroatoms selected - 2 -independently between nitrogen, sulfur and oxygen, optionally having any of said rings partially saturated or fully saturated one or more groups oxo substituted on carbon; said residues Ar and Ar1, in the case of a ring of five to eight fully unsaturated elements, a bicyclic ring or a tricyclic ring, and said Ar2 residues are independently optionally substituted on carbon, in a ring if the remainder is monocyclic, in one or both rings if the remainder is bicyclic, or in one, two or three rings if the remainder is tricyclic, with up to three substituents selected from R1, R2 and R3, R1, R2 and R3 independently being hydroxy, nitro, halogen , (C1-C7) alkoxy, (C1-C4) alkoxy (C1-C4) alkyl, (C1-C4) alkoxycarbonyl, (C1-C7) alkyl, (C2-C7) alkenyl, (C2-C7) alkynyl, cycloalkyl (C3-C7), cycloalkyl (C3-C7) alkyl (C1-C4), cycloalkyl (C3-C7) alkanoyl (C1-C4), formyl, alkanoyl (C1-C8), alkanoyl (C1-C6) alkyl (C1 -C6), aminocarbonylamino or aminocarbonylamino mono N-, di-N, N-, di-N, N´ or tri-N, N, N´-C1-C4 alkyl substituted, alkanoylamino (C1-C4), alkoxycarbonylamino (C1-C4), sulfonamido, hydroxysu lfonyl, alkylsulfonamido (C1-C4), amino, mono-No-di-N, N-alkylamino (C1-C4), carbamoyl, mono-N- or di-N, N-alkylcarbamoyl (C1-C4), cyano, thiol , alkylthio (C1-C6), alkylsulfinyl (C1-C6), alkylsulfonyl (C1-C4) or mono-N- or di-N, N-alkylaminosulfinyl (C1-C4); R1, R2 and R3, when they contain an alkyl, alkenyl, alkylene or alkenylene moiety, are optionally straight or branched chain and are optionally mono, di- or tri substituted on carbon independently with halogen or hydroxy; and V is a bond, -CO- or (C1-C3) alkylene optionally mono or independently substituted with hydroxy or fluoro, with the proviso that (1) when L is -CO-, A is hydroxy and (2) when L it is a bond and M is phenyl, said phenyl is substituted with one to three substituents selected from R1, R2 and R3. |
| priorityDate | 1997-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.