http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CO-5080733-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_938a6d7a15cbc93a74abe1953eb25d47 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-125 |
| filingDate | 1997-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc3e8c152caeb8edbccf178854981ca9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe55ea70b5b6a8d3fce2971242916507 |
| publicationDate | 2001-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CO-5080733-A1 |
| titleOfInvention | METHODS AND COMPOSITIONS TO STIMULATE THE GROWTH OF NEURITES |
| abstract | A pharmaceutically acceptable composition comprises: a) .- A neurotrophic amount of a compound containing the formula (I) <EMI FILE = "97066753_1" ID = "1" IMF = JPEG> and pharmaceutically acceptable derivatives thereof, wherein: A is CH2, oxygen, or NR1; wherein R1, B and D are independently: hydrogen, Ar, straight or branched (C1-C6) alkyl, straight or branched alkenyl or (C2-C6) alkynyl, (C1-C6) alkyl straight or branched substituted with cycloalkyl (C5-C7), straight or branched alkenyl or alkynyl (C3-C6) substituted with cycloalkyl (C5-C7), straight or branched alkyl (C1-C6) substituted with cycloalkenyl (C5-C7), straight or branched (C3-C6) alkenyl or alkynyl substituted with (C5-C7) cycloalkenyl, straight or branched (C1-C6) alkyl substituted with Ar, or straight or branched (C3-C6) alkenyl or alkynyl substituted with Ar; wherein any of the CH2 groups of said alkyl chain at R1, B and D are optionally replaced by 0, S, SO, SO2, or Nr; where R is hid halogen, straight or branched (C-C4) alkyl, alkenyl or alkynyl or branched (C3-C4), or dotted (C1-C4) alkyl wherein the bridge is formed between the nitrogen and the carbon atom of said alkyl chain to form a ring, and where said ring is optionally fused with Ar; J is selected from hydrogen, straight or branched (C1-C6) alkyl straight or branched alkenyl with (C3-C6), or -CH2 Ar; K is selected from straight or branched (C1-C4) alkyl, -CH2 Ar, or cyclohexylmethyl; oJ and K are taken together with nitrogen or carbon atoms to which they are bound respectively to form a heterocyclic ring with 5 to 7 members that optionally contain a heteroatom selected from 0, S, SO, SO2; Z is 0 or S; - 2 -Y is O or N, where, when Y is 0, then R1 is a single pair and R2 is selected from Ar, straight or branched alkyl (C1-C6), or straight or branched alkenyl (C3- C6); and when Y is N, then R1 and R2 are independently selected from the group consisting of Ar, straight or branched (C1-C6) alkyl, or straight or branched alkenyl or alkynyl with (C3-C6); or R1 and R2 are taken together to form a 5- to 6-membered heterocyclic ring selected from pyrrolidine, imidazolidine, pyrazolidine, piperidine, or piperazine; wherein Ar is a carboxylic aromatic group selected from the group consisting of phenyl, 1- naphthyl, 2-naphthyl, indenyl, azulenyl, fluorenyl or anthracenyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, 2-pyrazolinyl, pyrazolidinyl, isoxazolyl, isotriazolyl, 1,2,3-oxadiazolyl, 1, 2,3-triazolyl, 1,3,4-thiadiazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, 1,3,5-triazinyl, 1,3,5-trityanyl, indolizinyl, isoindolyl, 3H-indolyl, indolinyl, benzo [b] furanyl, benzo [b] thiophenyl, 1H-indazolyl, benzimidazolyl, benzithiazolyl, purinyl, 4H-quinolizinyl, quinolinyl, 1,2, 3,4-tetrahydro-isoquinolinyl, isoquinolinyl, 1,2,3,4-tetrahydro-isoquinolinyl, cinnolinyl, eftalazinyl, quinazolinyl, quinoxalinyl, 1,8-na ftiridinyl, pteridinyl, carbazolyl, acridinyl, phenazinyl, phenothiazinyl or phenoxazinyl; wherein Ar is optionally substituted with one or three substituents independently selected from hydrogen, halogen, hydroxyl, nitro, SO3H, trifluoromethyl, trifluoromethoxy, straight or branched (C1-C6) alkyl, straight or branched (C2-C6) alkenyl, or- [straight or branched (C1-C6) alkyl], or - [straight or branched (C3-C4) alkenyl], o-benzyl, o-phenyl, 1,2-methylenedioxy, -R3 R4, carboxyl, N- (alkyl straight or branched (C1-C5) or straight or branched alkenyl (C3-C5) carboxamides, N, N-di- (straight or branched alkyl (C1-C5) or straight or branched alkenyl (C3-C5) carboxamide, morpholinyl, piperidinyl, OZ, CH2- (CH2) q -Z, 0- (CH2) q -Z, (CH2) q -ZOZ, or CH = CH-Z; where R3 and R4 are independently selected from straight alkyl or branched (C1-C6) straight or branched (C3-C6) alkenyl hydrogen or benzyl; or wherein R3 and R4 are taken together to form a 5-6 membered heterocyclic ring; wherein Z is selected from 4-methoxyphenyl , 2-pyridyl, 3-pyrid yl, 4-pyridyl, pyrazyl, quinolyl, 3,5-dimethylisoxazoyl, 2-methylthioazoyl, thiazoyl, 2-thienyl, 3-thienyl, 4-thienyl or pyrimidyl; where q is 0-2; and n is 0 or 1; b) a neurotrophic factor; and c) a pharmaceutically suitable carrier. |
| priorityDate | 1996-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.