| abstract |
A compound of the formula (I), or a tautomeric form, pharmaceutically acceptable salt or solvate thereof, <EMI FILE = "99049333_1" ID = "1" IMF = JPEG> characterized in that: R1 is hydrogen or C1-3 alkyl; R2 is hydrogen or C1-8 alkyl optionally substituted by one or more halogens; R3 is C1-6 alkyl, C4-7 cycloalkyl or cycloalkenyl, -OC1-6, -NR´R 'alkyl, wherein each R' is independently hydrogen or C1-3 alkyl, a 5- or 6-membered heterocyclic group containing at least one oxygen, nitrogen or sulfur ring atom optionally substituted by one or more of halogen, C1-6 alkyl optionally substituted by one or more halogens, -OC1-6 alkyl optionally substituted by one or more halogens, -CN or - NO2, or phenyl optionally substituted by one or more halogen, C1-6 alkyl optionally substituted by one or more halogens, -OC1-6 alkyl optionally substituted by one or more halogens, -CN or -NO2; R4 is a 5 or 6 membered heterocyclic group containing at least one oxygen, nitrogen or sulfur ring atom optionally substituted by one or more halogen, C1-6 alkyl optionally substituted by one or more halogens, -OC1-6 alkyl optionally substituted by one or more halogens, -CN or -NO2, or phenyl optionally substituted by one or more halogen, C1-6 alkyl optionally substituted by one or more halogens, -OC1-6 alkyl optionally substituted by one or more halogens, - NR 'R' as defined above, -CN or -NO2; R5 is hydrogen, halogen or C1-3 alkyl optionally substituted by one or more halogens; R6 is hydrogen or C1-3 alkyl; X is O or S; and n is 1, 2 or 3. |