| abstract |
New substituted 1H-indazoles 1, 5 and 3-0- characterized because they have the general formula Id where X, Y, Z, R1, R2, and R3 have the following meaning: X can be -SO2 -, -SO-, - (CH2 ) p -, - (CH2) p -O-, - (CH2) p - (C = O) - - (CH2) p - (C = O) -NH, - (CH2) p -CHOH-, -CHOH - (CH2) p -, - (CH2) p -CH = CH-, - CH = CH- (CH2) p -con p = 1 ... 4, and can be - (CH2) p -, - (CH2 ) p -O-, - (CH2) p - (C = O), - (CH2) p - (C = O) -NH-, - (CH2) p - (C = O) -NH- (CH2) p -, - (CH2) p -CHOH-, -CHOH- (CH2) p -, - (CH2) p -CH = CH, -CH = CH- (CH2) p - with p = 1 ... 4, Z can be -O-, -S-, -SO-, -SO2 -, -O- (CH2) p - with p = 1 ... 4, -NH-, -NH- (C = O), - NH- (C = O) -NH, -NH- (C = O) -O-, -NH-CH2 - (C = O) - and -NH- (C = O) -CH2, R1, R2 and R3 they can be the same or different and can have the following meaning: Mono, bi or tricyclic saturated or one or more unsaturated carboxycycles, with 5 ... 14 links, especially phenyl, naphthyl, anthranyl, fluorenyl; or saturated mono, bi or tricyclic heterocycles or one or more unsaturated, with 5 ... 15 links and 1 ... 6 heteroatoms that are preferably N, O and S, especially thiophenyl, pyridinyl, isoxazolyl, benzimidazolyl, benz [1 , 3] dioxolyl, pyrimidinyl, quinylyl, quinazolinyl, morpholinyl, pyrrolidinyl, phenyl [1,2,4] oxadiazolyl, phenylthiazolyl, where carbocycles or, where appropriate, heterocycles ... |