| abstract |
1,2-Dihydro-indazol-3-one 1,2,5-trisubstituted compounds characterized in that they have the general formula where X, Y, Z, R1, R2 and R3 have the following meaning: X can be -SO2 -, - SO-, - (CH2) p -, - (CH2) p -O-, - (CH2) p - (C = O) - - (CH2) p - (C = O) -NH, - (CH2) p -CHOH-, -CHOH- (CH2) p -, - (CH2) p -CH = CH-, CH = CH- (CH2) p - with p = 1 ... 4, Y can be - (C = O ) -, - (C = O) -NH, - (C = O) -NH- (CH2) p -, - (C = O) - (CH2) p-, - (CH2) p -, - (CH2 ) p -O-, - (CH2) p - (C = O), - (CH2) p - (C = O) -NH-, - (CH2) p- (C = O) -NH- (CH2) p -, - (CH2) p -CHOH, -CHOH- (CH2) p -, - (CH2) p -CH = CH, -CH = CH- (CH2) p - with p = 1 ... 4, Z it can be -O-, -O- (CH2) p - with p = 1 ... 4, -NH-, -NH- (C = O), -NH- (C = O) -NH, -NH ( C = O) -O-, -NH-CH2 - (C = O) - and -NH- (C = O) -CH2, R1, R2 and R3 can be the same or different and can have the following meaning: Mono Carbocycles , bi or tricyclics saturated or one or more times unsaturated, with 5 ... 14 links especially phenyl, naphthyl, anthranyl, fluorenyl; or saturated mono, bi or tricyclic heterocycles or one or more unsaturated, with 5-15 links and 1 ... 6 heteroatoms that are preferably N, O and S, especially thiophenyl, pyridinyl, isoxazolyl, benzimidazolyl, benz [1,3 ] dioxolyl, pyrimidinyl, quinolyl, quinazolinyl, morpholinyl, pyrrolidinyl, pyrrolyl, phenyl [1,2,4] oxadiazolyl, phenylthiazolyl, where the carbocycles or, where appropriate, the heterocycles may be one or more times substituted by ... |