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filingDate 1998-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00389fefd2220435cc2a7af97889f561
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publicationDate 2000-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CO-4960666-A1
titleOfInvention NEUTRALIZATION OF LOADS WITH ARGINYL OF EPRO-SARTAN AND A PROCEDURE FOR ITS PRODUCTION AND FORMULATION
abstract A compound that is an arginyl charge neutralization complex of (E) -a- [2-n-butyl-1 - [(4- carboxy-phenyl) methyl] -1H-imidazol-5-yl] methylene-2 -thiophene-propionic. A process for the preparation of the composition according to claim 5, comprising: (i) mixing the (E) -a- [2-n-butyl-1 - [(4-carboxyphenyl) methyl] -1H- acid imidazol-5-yl] methylene-2-thiophene-propionic acid or its methanesulfonate salt and L-arginine with one or more pharmaceutically acceptable carriers. (ii) granulate the mixture with water; and (iii) drying the granulate to a predetermined water content. 5A pharmaceutical composition comprising (E) -a- [2-n-butyl-1 - [(4-carboxyphenyl) methyl] -1H-imidazol-5-yl] methylene-2-thiophene-propionic acid or its methanesulfonate salt, a charge neutralizing complexing agent and a pharmaceutically acceptable carrier.
priorityDate 1997-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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