| abstract |
This invention relates to benzoxacinone compounds that are dopamine D4 receptor antagonists, characterized by formula I or II where R1 and R2 are independently hydrogen or C1-C6 alkyl, X is N or CH; and R3 is phenyl, naphthyl, heteroaryl, substituted phenyl, substituted naphthyl or substituted heteroaryl, where each substituent is independently selected from halogen, C1-C6 alkoxy, C1-C6 alkyl, -CN, CF3 or sulfonamido and its salts, esters, amides and The pharmacologically acceptable prodrugs. The invention further relates to the application of such compounds to treat psychosis and schizophrenia, and to pharmacologically acceptable compositions containing such compounds that are D4 dopamine receptor antagonists. |