http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CO-4930296-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05ff905fdc49089f5f25746eaeb40190 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F- |
| filingDate | 1998-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08a1a2024b922869109dc8b443305f8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04cf503227aef7d3599d1cdaea3e9f7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f42350c72c43d886e98c714600611fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f000dec13856a43b42397703c0b45d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0f9968fc0b4220821ea06a7e6d7dfa4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78d760643a8fc54df7dcb373090e13cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b58e42e2eb3e12de383c76ed1c1a282c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4d768d50d03ce6c0909a4c0e1a03d60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a29c28d3a82d5d05fdb032076219fa0a |
| publicationDate | 2000-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CO-4930296-A1 |
| titleOfInvention | PYRID [2,3-D] PYRIMIDINES AND 4-AMINOPYRIMIDINES AS INHIBITORS OF CELL PROLIFERATION |
| abstract | A compound of formula IO a pharmaceutically acceptable salt obtained from them, where: the dotted line represents an optional double bond; W is NH, S, SO or SO2; X is O, or NH; R1 and R2 are independently selected from the group consisting of H, Ar (CH2) n, heteroaryl (CH2) n, heterocyclyl (CH2) n, C1-C10 alkyl, C3-C10 cycloalkyl, C2-C10 alkenyl , and C2-C10 alkynyl, where n is 0, 1, 2, or 3 and the groups Ar (CH2) n, heteroaryl, alkyl, cycloalkyl, alkenyl, and alkynyl (CH2) n, are optionally substituted by up to 5 groups selected from NR4 R5, N (O) R4 R5, NR4 R5 R6 Y, phenyl, substituted phenyl, hydroxy, alkoxy, phenoxy, thiol, thioalkyl, halo, COR4, CO2 R4, CONR4 R5, SO2 NR4 R5, SO3 R4, PO3 R4, aldehyde, nitrile, nitro, heteroaryloxy, T (CH2) m QR4, C (O) T (CH2) m QR4, NHC (O) T (CH2) m QR4, or T (CH2) m CO2 R4, where each m is 1-6, T is O, S, NR4, N (O) R4, NR4 R6 Y or CR4 R5, and Q is O, S, NR5, N (O) R5, or NR5 R6 Y; R3 is H, alkyl. R4 and R5 are each independently selected from the group consisting of hydrogen, C1-C6 alkyl substituted alkyl, C2-C6 alkenyl, C2-C6 alkynyl Ar (CH2) n cycloalkyl, heterocyclyl and C3-C10 or R4 and R5 heteroaryl together with the nitrogen to which they are optionally attached form a chain consisting of 3 to 7 carbon atoms and said chain optionally contains 1, 2 or 3 heteroatoms selected from the group consisting of nitrogen, substituted nitrogen, oxygen and sulfur; R6 is alkyl; R8 and R9 independently are H, C1-C3 alkyl, NR4 R5, N (O) R4 R5, NR4 R5 R6 Y, hydroxy, alkoxy, thiol, thioalkyl, halo, COR4, CO2 R4, CONR4 R5, SO2 NR4 R5, SO3 R4, PO3 R4, CHO, CN or NO2 and Y is a halo counter ion. |
| priorityDate | 1997-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.