| abstract |
THE PRESENT INVENTION PROVIDES A COMPOUND OF FORMULA (I): IN WHICH AR IS (a) PHENYL, NAPHTHYL AND BIPHENYL, EACH OPTIONALLY REPLACED WITH C1-4 ALKYL, HALOALKYLL C1-4, HYDROXIALKYL C1-4, ALCO-XI C1-4, HALOALCOXI C1-4, ALCOXIALCOXI C2-4, AL- QUILTIO C1-4, HIDROXI, HALO, AMINO, ALQULAMINO C1- 4, DIALQUIL (C2-8) AMINO, ALCANOILAMINO C2-6, CARBOXI, ALCOXICARBONILO C2 6 O FENILO, FENOXI, FENILTIO OR FENILSULFINILO, OPTIONALLY SUBSTITUTED OR (b) FURILO, BENZO [b] FURILI, TIENILO, BENZO [b] TIENILO, PIRIDILO OR QUINOLILO, ALSO OPTIO-NUT, ALSO HALOALKYL C1-4, HALO ALCOXY C1-4, FENYL FENOXY AND FENYLTIUM OPTIONALLY SUBSTITUTED X IS ALKYLENE C1-C4, ALKYLENE C2-C4, - (CHR1) m-Q1- (CHR2) n, -O- (CHR1) -Q2- and (CHR1) -ON =, WHERE THE RADICAL N = 2, IS ATTACHED TO THE CYCLOALQUENE RING; AND IN WHICH 0 [1] IS O, S, SO, NR3, CH = NO or CO, Q2, is O, S, SO, SO2 or NR3, AND R1, R2 AND R3 ARE, EACH, HYDROGEN OR ALKYL C1-C4, m and n ARE, EACH ONE, A WHOLE NUMBER FROM 0 TO 4 AND j IS A WHOLE NUMBER FROM 1 TO 4; p IS THE WHOLE NUMBER 1 or 2; AND IT IS HYDROGEN, C1-4 ALKYL; C1-4 HALOALKYL, C1-4 ALCOXY, ALCOXY- C2-4 ALKYL, C1-4 ALKYL, HYDROXY, HALO, CIA- NO OR AMINO; Z IS HYDROGEN OR C1-4 ALKYL; AND M IS HYDROGEN, A PHARMACEUTICALLY ACCEPTABLE CATION OR A METABOLICALLY PHARMACEUTICALLY ACCEPTABLE GROUP. IN ADDITION, THE INVENTION PROVIDES A PHARMACEUTICALLY COMPOSITION TO TREAT A MEDICAL DISORDER FOR WHICH A 5-LIPOXYGENENE INHIBITOR IS NECESSARY IN A MAMMAL, WHICH INCLUDES A COMPARISON OF THAN ONE UNIT AND ONE COMPUENT OF ONE COMPUTAINLY . PREFERABLY, THE MEDICAL DISORDER IS AN INFLAMMATORY DISEASE, AN ALLERGY, OR CARDIOVASCULAR DISEASES. FIGURE 1 |