| abstract |
THE INVENTION PROVIDES FORMULA I COMPOUNDS, IN WHICH R1 REPRESENTS ALCOXI C1-4 OPTIONALLY REPLACED WITH ONE OR MORE ATOMS OF FLUORIDE; R2 REPRESENTS H or ALCOXI C1-6 OPTIONALLY SUBSTITUTED WITH ONE OR MORE FLUOR ATOMS; R3 REPRESENTS ONE OR MORE INDEPENDENTLY SELECTED GROUPS BETWEEN H, HALOGEN, ALCOXI C1-4 AND CF3; IN ADDITION, R2 AND A GROUP R3 MAY REPRESENT TOGETHER -OCH2-, THE METHYLENE GROUP BEING UNITED TO THE ORTO POSITION OF THE PENDANT PHENYLIC RING; R4 REPRESENTS A 4, 5 OR 6 MEMBER HETERO CYCLIC RING CONTAINING 1 OR 2 SELECTED HETEROATOMES BETWEEN N, O and S, THE RING IS OPTIONALLY CONDENSED TO A BENZENE RING OR A 5 OR 6 HETERO CYCLIC RING MEMBERS CONTAINING 1 or 2 SELECTED HETEROATOMES BETWEEN N, O and S, THE GLOBAL RING SYSTEM BEING OPTIONALLY REPLACED; X REPRESENTS CH or N; AND HE IS ABSENT OR REPRESENTS A CYCLICAL GROUP OR AN OPEN CHAIN GROUP; AND SALTS PHARMACEUTICALLY ACCEPTABLE THEREOF. THE FORMULA I COMPOUNDS ARE USEFUL IN THE TREATMENT OF, BETWEEN OTHERS, BENIGN PROSTATIC HYPERPLASIA. FIGURE 1 |