http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CO-4290415-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_edf293c68960c070624bc691096cae55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-12 |
| filingDate | 1994-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_564187a67bbccd266ce27e386b051513 |
| publicationDate | 1996-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CO-4290415-A1 |
| titleOfInvention | NEW AMINO ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY |
| abstract | 1. A COMPOUND OF FORMULA (I): WHERE R1, BYD ARE INDEPENDENTLY: Ar, ALKYL STRAIGHT OR BRANCHED (C1-C6), ALKENYL OR ALKYL STRAIGHT OR BRANCHED (C2-C6), CYCLOALKYL SUBSTITUTED (C5-C7) ALKYL STRAIGHT OR BRANCHED C1-C6), CYCLOALKYL SUBSTITUTED (C5-C7) ALKENYL OR ALKYL STRAIGHT OR BRANCHED (C3-C6), CYCLOALKENYL SUBSTITUTED (C5-C7) ALKYL STRAIGHT OR BRANCHED (C1-C6), CICLOALKYL (C3-C6) ) ALKENYL OR ALKINYL (C3-C6), Ar SUBSTITUTED ALKYL STRAIGHT OR BRANCHED (C1-C6), Ar SUBSTITUTED ALKENYL OR ALKINYL STRAIGHT OR BRANCHED (C3-C6); WHERE ANY OF THE CH2 GROUPS OF SUCH ALKILO CHAINS CAN BE OPTIONALLY REPLACED BY A SELECTED HETEROATOMO FROM THE CONSISTENT GROUP OF O, S, SO, SO2, AND NR, WHERE R IS SELECTED FROM THE CONSISTENT GROUP OF OIDROGEN BRANCHED (C1-C4), ALKENYL OR ALKINYL STRAIGHT OR BRANCHED (C3-C4), AND LINK ALKYL (C1-C4) WHERE A BRIDGE IS FORMED BETWEEN NITROGEN AND A CARBON ATOM OF SUCH CHAIN THAT CONTAINS A HETEROATOM TO FORM A RING AND WHERE SUCH A RING IS OPTIONALLY MERGED TO AN AR GROUP; B AND D MAY ALSO BE HYDROGEN; WHEREAS R1 IS NOT NITROGEN; J IS SELECTED FROM THE GROUP CONSISTING OF STRAIGHT OR BRANCHED ALKYL (C1-C6), STRAIGHT OR BRANCHED ALKENYL (C3-C6), AR SUBSTITUTED STRAIGHT OR RAMIFIED (C1-C6), AND Ar SUBSTITUTED ALKENYL OR AL- KINYL STRAIGHT OR BRANCHED (C3-C6); K IS SELECTED FROM THE GROUP CONSISTING OF STRAIGHT OR BRANCHED ALKYL (C1-C6), AR SUBSTITUTED STRAIGHT OR BRANCHED (C1-C6), AR SUBSTITUTED ALKENYL OR STRAIGHT OR BRANCHED ALKILINE (C2-C6), AND CYCLLOHEXYL-METHYL; X IS SELECTED FROM THE CONSISTENT GROUP OF AR, -OR2, AND -NR3R4; WHERE R2 HAS THE SAME DEFINITION OF R1; AND R3 AND R4 INDEPENDENTLY HAVE THE SAME DEFINITIONS OF B AND D, AND R3 AND R4 ARE TAKEN TOGETHER TO FORM A 5-7 MEMBER ALIPHATIC CYCLING RING; WHERE Ar IS A CARBOCICLIC AROMATIC GROUP SELECTED FROM THE CONSISTENT GROUP OF FENYL, 1-NAFTHYL, 2NAPHYLL, INDENYL, AZULENYL, FLUORENYL AND ANTHRACHENYL; O Ar IS A SELECTED HETERO-CYCLE AROMATIC GROUP OF THE GROUP CONSISTS OF 2-FURYL, 3-FURYLL- 2-THIENYL, 2-PIRIDYL, 3-PIRIDYL, 4-PIRIDYL, OXAZOLYL, OXAZOLYL, 2-PIRAZOLINYL, PIRAZOLIDINYL, ISOXAZO- LILO, ISOTRIAZOLYL, 1,2,3-OXADIAZOLYL, 1,2,3-TRIAZOLYL, 1,3,5-TRIAZINYL, 1,3,5-TRIHIANYL, INDOLIZINYL, INDOLYL, ISOINDOLYL 3H-INDOLYL, INDOLINYL, BENX: B: FURANYL, BENZ: B: THIOPHENYL, 1H-INDAZOLYL, BENZIMIDAZOLYL, BENZTHIAZOLYL, PURINYL, 4H-QUINOLYZINYL, 1,2,3,4-TETHYRINYL, QUINYLIN, 1,2-QUINHYLIN, 1,2-QUINHYLIN, 1,2-QUINHYLIN-1,2-QUINYLIN 3,4-TETRAHYDRO- ISOQUINIOLINYL, CINNOLINYL, FTALAZINYL, QUINA- ZOLINILO, QUINOXALINILO, 1,8-NAFTIRIDINILO, PTERI- DINILO, CERBAZOLILO, ACRIDINILO, FANAZINILO, FENO- THAZINO WHERE AR MAY CONTAIN ONE OR MORE SUBTITUENTS THAT ARE SELECTED INDEPENDENTLY FROM THE CONSISTENT GROUP OF HYDROGEN, HALOGEN, HYDROGEN, NI- TRO-SO3H, TRIFLUOROMETILO, TRIFLUOROMETOXI, ALKI- OTO-RECTO C2-C6), OR [STRAIGHT OR BRANCHED ALKYL (1, C6)], or [STRAIGHT OR BRANCHED ALKENYL (C3-C4)], O-BENCILO, OR PHENYL, 1,2-METHYLENEDIOXI, -NR5R6, CARBOXYL, N - (ALKYL STRAIGHT OR BRANCHED C1-C5 OR ALKENYL STRAIGHT OR BRANCHED (C3-C5) CARBOXAMIDES, N, N, -DI-ALKYL STRAIGHT OR BRANCHED (C1-C5) OR ALKE- NILE STRAIGHT OR TAMIFIED (C3-C5) CARBIXAMIDES , MOR- FOLINILO, PIPERIDINILO, OM, CH2-CH2) qM, O- (CH2) qM, O- (CH2) qM, (CH2) qOM, AND CH = CH-M WHERE R5 AND R6 ARE SELECTED INDEPENDENTLY FROM THE CONSISTENT GROUP OF HYDROGEN, STRAIGHT OR BRANCHED ALKYL (C1-C6), ALKENYL OR STRAIGHT OR BRANCHED ALKYLINE (C3-C6) AND BENCILUM; M IS SELECTED FROM THE CONSISTENT GROUP OF 4-METOXIFENILO, 2-PIRIDILO, 3-PIRIDILO, 4-PIRIDILO, PIRAZILO, QUINOLILO, 3,5-DIMETILSOXAZOILO, 2-METHYLTHIAZYL, THAZOILO, 2-THIENOIL ; Y q IS O-2; And m IS O or 1. |
| priorityDate | 1994-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 18.