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publicationDate 2022-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CO-2022012809-A2
titleOfInvention Human alpha-galactosidase variants
abstract The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. Engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, stability in serum, improved cellular uptake, stability under both acidic (pH <4) and basic (pH >7) conditions, reduced immunogenicity, and scavenging of globotriaosylceramide. of cells enhanced. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
priorityDate 2020-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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