abstract |
The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. Engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, stability in serum, improved cellular uptake, stability under both acidic (pH <4) and basic (pH >7) conditions, reduced immunogenicity, and scavenging of globotriaosylceramide. of cells enhanced. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes. |