abstract |
The invention relates to PCSK9 inhibitors useful in the treatment of cholesterol lipid metabolism and other diseases in which PCSK9 is involved, having the formula (I): (I), or a salt, hydrate, solvate, prodrug , stereoisomer, N-oxide or pharmaceutically acceptable tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein. |