| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f52c68e4149a6c462b850d4e7cc2b2f9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate |
2020-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8c3d8d37a09787ebb8e888df932af02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e5066c1ec9e1936dc80627a6b5f6955
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b4fa578425d58a2be222451ed24b566 |
| publicationDate |
2020-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CO-2020013150-A2 |
| titleOfInvention |
Process for preparing (4s) -4- (4-cyano-2-methoxyphenyl) -5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide by separation of racemate by ester of diastereomeric tartaric acid |
| abstract |
The present invention relates to a new and improved process for the preparation of (4S) -4- (4-cyano-2-methoxyphenyl) -5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6 -naphthyridine-3-carboxamide of the formula (I) (I), and the preparation of the enantiomer (Ia) by racemate separation with chirally substituted tartaric acid esters of the general formulas (IIIa) and (IIIb) (Ia) ( IIIa) (IIIb) where Ar is a substituted or unsubstituted aromatic or heteroaromatic compound. |
| priorityDate |
2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |