| abstract |
Small molecule calpain modulator compounds, including their pharmaceutically acceptable salts, can be included in pharmaceutical compositions. The compounds may be useful for inhibiting calpain or competitive binding with calpastatin by contacting them with CAPN1, CAPN2, and / or CAPN9 enzymes residing within a subject. The compounds and composition can also be administered to a subject for the purpose of treating a fibrotic disease or a secondary disease state or fibrotic disease condition. |