| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a73cee5001ad08339ae751c10d9abf71 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-61 |
| filingDate |
2020-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9f32a7c8d6006eba9ebbba433810b32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f38a2b685aedb3b1bbfd1797bc1a155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81febb830af4791c6d20a380cbc4eadc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53d75532232d0dc995a62029f3334643 |
| publicationDate |
2020-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CO-2020009994-A2 |
| titleOfInvention |
Processes for preparing (1- (3-fluoro-2- (trifluoromethyl) isonicotinyl) piperidine-4-one) |
| abstract |
The present invention relates to processes and intermediates for making {1- {1- [3-fluoro-2- (trifluoromethyl) isonicotinoyl] piperidin-4-yl} -3- [4- (7H-pyrrolo [2,3- d] pyrimidin-4-yl) -1H-pyrazol-1-yl] azetidin-3-yl} acetonitrile, useful in the treatment of diseases related to Janus kinase activity (JAK) including inflammatory disorders, autoimmune disorders, cancer and other diseases. The invention is specifically directed to processes for making intermediate (1- (3-fluoro-2- (trifluoromethyl) isonicotinyl) piperidine-4-one) from 1- (3-fluoro-2- (trifluoromethyl) isonicotinoyl chloride and 4-hydroxypiperidine or 5-piperidone as well as the 1- (3-fluoro-2- (trifluoromethyl) isonicotinoyl chloride intermediate. |
| priorityDate |
2018-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |