| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_00cf135003c69ae281b696d3bc73e0c9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-123
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39591
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2878
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1133
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate |
2017-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7fba0e86c0abaafaa2568ccc0aaeed6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa08324ab5b09231f2b3d0ecf9b7256e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c7f68393179a8689ef7d542b396c587
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac9fde96fe84f6c162112ec17d74f0f7 |
| publicationDate |
2018-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CO-2017010385-A2 |
| titleOfInvention |
Recombinant antibody molecule monomerization method |
| abstract |
The present invention provides a method for increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules, characterized in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising a VH and a VL, wherein said VH and VL are directly or indirectly connected through one or more linkers and are stabilized by a disulfide bond between them, said method comprises: a) a conversion step to treat the composition with a denaturant selected from urea and / or guanidine hydrochloride; b) wherein step a) is carried out in the presence of a reducing agent or after treatment with a reducing agent. |
| priorityDate |
2015-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |