| abstract |
The utility model relates to a hollow silk fibroin microneedle structure, its needle body shell are by the basement and evenly plant row and forms in the hull shape needle body that this basement side surface and inside cavity formed the aciculiform cavity, and the interior cystica of aciculiform cavity has model medicine portion, has greatly increased the medicine carrying volume of micropin, it often needs in addition the area to store up defects such as drug storage, pressure control device to compare traditional hollow micropin, and this application is through with model medicine cystica in the inside cavity of hull shape needle body and the pressure of production after combining swelling intermediate layer swelling to and the swelling action behind the needle body shell contact body fluid, impel the model medicine to see through the micropore release of aquogel form needle body shell, release the medicine rate high, release that medicine speed is big, controlled release nature is excellent, hull shape needle body among this application hollow silk fibroin microneedle structure pointed end is fragile hard and soluble micro molecule silk fibroin solidfied material in addition, possesses sufficient brute force during the dry state and thrusts skin, dissolves rapidly behind the contact body fluid and forms the most advanced entity pore of needle body, has promoted greatly that the transdermal of model medicine releases. |