| abstract |
The present invention relates to the field of biotechnology or genetic engineering. In particular, the invention relates to the field of gene expression. More specifically, the present invention relates to novel substitution-mutant receptors, and their use in nuclear receptor-based inducible gene expression systems, and methods of modulating gene expression in host cells, useful in various applications such as Gene therapy, large-scale production of proteins and antibodies, cell-based high-throughput screening assays, functional genomics, and modulating traits in genetically modified organisms. |