http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-1915990-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d0ebea9bc14adaae5136e2c4d4d385b5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 |
| filingDate | 2006-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c20d54f7e8a7c3a020ad8e871f42f280 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9df9fcad9a9dd2e8c9894e5fc3a3a377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f428bf5e4870a82a2d5996e7a86f46ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f4e086c266e2a91236d360f2dd900b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4944b3af680051840a65283ef760210 |
| publicationDate | 2011-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-1915990-B |
| titleOfInvention | Method for preparingLosartan |
| abstract | This invention discloses a method for synthesizing losartan. The method comprises: reducing 2-butyl-4-chloro-5-aldehyde imidazole with a reducer (such as KBH4), and then reacting with 2'-cyano-4-bromomethyl biphenyl, or firstly reacting with 2'-cyano-4-bromomethyl biphenyl, and then reducing with KBH4 to obtain intermediate 2-butyl-4-chloro-5-hydroxymethyl-1-[(2'-cyano)-biphenyl-4-methyl]imid azole, which can react with sodium azide to obtain losartan. The method has such advantages as easy control, simple process, wide raw materials, convenient and safe operation, high yield and low cost. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103086979-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103086979-B |
| priorityDate | 2006-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.