| abstract |
The present invention relates to a cyclopentyl compound of formula (I) which is linked to a benzoxazinyl group and substituted by a heterocyclic group through an amide moiety which utilizes the ring nitrogen atom of the benzoxazine. Such compounds can be used to regulate CCR-2 chemokine receptors to prevent or treat inflammatory immunomodulatory disorders and diseases; allergic diseases; atopic disorders, including allergic rhinitis, dermatitis, conjunctivitis, and asthma; and autoimmune disorders (such as rheumatoid arthritis) and atherosclerosis; also to pharmaceutical compositions comprising these compounds and to uses of these compounds and compositions. |