| abstract |
Protein kinase, such as CHK-1, inhibiting tricyclic compounds of the following formula (wherein R<2>, R<3> and R<4> are as defined in the specification) pharmaceutical compositions containing effective amounts of said compounds or their salts are useful as a single agent or in combination with an anti-neoplastic agent or therapeutic radiation having an anti-neoplastic effect for treating diseasesor conditions, such as cancers. |