| abstract |
The present invention relates to (-)3-((S)-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)(3-thienyl)methyl)phenol and pharmaceutically acceptable esters or salts thereof, in substantially enantiomerically pure form, useful as receptor binding substances, e.g., as therapeutic agents for mediating analgesia; as coadministered agents with various other Biologically active compositions comprising narcotics, barbiturates, analgesics, etc. co-administered for the reduction, treatment, reversal or prevention of drug-mediated respiratory depression caused directly or indirectly by the use of these various induced by a biologically active composition; and used as a conjugate in an agonist/antagonist pair for verifying/testing the function of receptors and neurotransmitters; and used as a therapeutic agent for combating drug addiction , alcohol addiction, heart disease, drug overdose, cough, pulmonary edema, diarrhea, respiratory and gastrointestinal disorders. |