| abstract |
Compounds and methods for inactivating pathogens in materials are disclosed, including compositions and methods for inactivating pathogens in biological materials, such as red blood cell preparations and plasma. The compounds and methods are useful in the treatment of materials intended for use in vitro or in vivo (eg, clinical trials or blood transfusions). The compound should be able to specifically bind and react with the nucleic acid and then degrade to produce breakdown products. The degradation reaction rate is preferably lower than the reaction rate with nucleic acids. |