| abstract |
The present invention relates to a novel type containing 2,3-disubstituted succinic acid or 2-monosubstituted or 2,3-disubstituted fumaric acid or maleic acid (trans (E)- or cis (Z) )-butenedioic acid) group of novel linkers, which link two or more small molecule drugs/cytotoxic agents through a specific coupling reaction with bisthiol groups on cell-binding molecules. The present invention also relates to methods of making such linkers, methods of using such linkers to prepare homogeneous conjugates, and the use of these conjugates in the treatment of cancer, infections and autoimmune diseases. |