| abstract |
The invention belongs to the technical field of analytical chemistry, and specifically discloses a method for detecting related substances in a cisatracurium besylate bulk drug, and more specifically, discloses a method for analyzing and detecting cisatracurium besylate bulk drug MediumBSA2, BSA‑B, BSA‑C, BSA‑D, BSA‑E, BSA‑F, BSA‑G, BSA‑H, BSA‑U, BSA‑L, BSA‑J, BSA‑M, BSA‑I and BSA‑K or a method for a drug containing the above 14 substances. In this application, the composition of buffer salts, the selection of pH regulators, the pH value of the solution, the gradient elution procedure and other conditions are optimized, and a suitable analysis method is finally established. Baseline separation can be achieved, with strong specificity, good reproducibility and high accuracy. |