abstract |
The invention discloses a RIPK1 inhibitor for inhibiting programmed cell necrosis and a preparation method thereof. The RIPK1 inhibitor of the present invention is shown in general formula I, wherein X, Y, Z, L, R 1 , R 2 , R 3 , R 4 , ring A, ring B and n are as described in the description and claims Show. The invention also discloses the preparation method of the general formula I and the test results of its activity of inhibiting programmed cell necrosis and RIPK1. The compounds of general formula I described in the present invention can be used to prepare medicines for the treatment and prevention of inflammatory and degenerative diseases. |