http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115245485-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52bc13eee05ca0fba8cbd19c9b51941f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-20 |
| filingDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07c7de67c6d51ff7911d2a6e57fc86db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8407d4984d21ec0496e02f5552ab6f7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7072ffeaf1f12df3162410136b548dcd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1a401e106e9ab0820daeb293f113c2f |
| publicationDate | 2022-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-115245485-A |
| titleOfInvention | A kind of preparation method of preservative-free cisatracurium besylate injection |
| abstract | The invention discloses a preparation method of atracurium besylate injection, which comprises the following steps: a. adding a certain amount of water for injection into a container, cooling the water for injection to below 20°C; b. using a pH adjuster Adjust pH to 3.0～3.8; c. Add cisatracurium besylate, stir until the solution is clear and no insoluble matter; d. Make up to volume with cooled water for injection; e. Fill with nitrogen after sterile filtration and seal; f. Use the color water method or the negative pressure leak detection method to perform leak detection, that is, it is obtained. In the present invention, the influence of temperature on product quality in the preparation process is controlled as much as possible in the preparation process of cisatracurium besylate, the production operation is simple, and it is more suitable for scaled-up production, and ensures that the cisatracurium besylate injection is safe in the production process. The impurities shall not exceed the standard within the validity period, and the content shall be kept above 90.0%. |
| priorityDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.