abstract |
The invention discloses an efficient preparation method of a sulfone group-substituted phosphorothioate compound. The main points of the technical solution of the present invention are as follows: adding olefinic compounds, dialkyl thiophosphate compounds, sulfonyl chloride compounds, photocatalysts, copper catalysts and alkalis into a solvent, under an inert gas atmosphere at 0-40° C. The reaction is stirred under visible light irradiation, and after the reaction is completed, the target product sulfone group-substituted phosphorothioate compound is obtained by post-treatment. The preparation method of the invention has cheap and easily available raw materials, mild reaction conditions, convenient operation, good substrate applicability, high yield, good step economy and good atom economy, and is suitable for industrial production. |