| abstract |
The invention discloses a polysubstituted benzene-based immunomodulatory compound, a composition and an application thereof, which have a structure represented by general formula (I). The inventors of the present invention have confirmed through experiments that the compound of the present invention exhibits strong PD-1/PD-L1 blocking activity, and can reverse the T cell function inhibited by PD-L1 at the same time. Meanwhile, the compound of the present invention can activate the NFAT signaling pathway caused by the combination of PD-1/PD-L1, can be orally absorbed, and has good pharmacokinetic properties. Accordingly, the compounds of the present invention may be used alone or in combination with other drugs in the treatment of diseases, disorders or conditions that benefit from inhibition of PD1 or PD-L1 activity, including infectious diseases, immune diseases, inflammation Sexual diseases and cancer. |