| abstract |
The invention discloses a temperature-sensitive modified chitin hydrogel-loaded local anesthetic sustained-release analgesic system, a preparation method and an application. Dissolve the thermosensitive chitin derivative in water at low temperature, add local anesthetic analgesic aqueous solution or degradable polymer microspheres loaded with local anesthetic analgesic in a liquid state, and mix uniformly at low temperature. It is injected into the site requiring local anesthesia and analgesia to rapidly form a gel at body temperature and release the drug slowly. The main feature of the local anesthetic sustained-release analgesic composite hydrogel system is that it is simple to prepare, does not use organic solvents, can slowly release local anesthetic analgesics, and solves the problem of existing local anesthetics such as bupivacaine hydrochloride and ropivacaine. It can completely fill irregular wounds, has good biocompatibility and biodegradability, and is conducive to long-term local anesthesia, analgesia, anti-inflammatory, anti-itching and promoting wound healing. effect. |